In US, 100 million now vaccinated against COVID-19

In 100 days, President Joe Biden has made good on his promise of delivering 100 million COVID-19 vaccines in arms. In truth, the United States has administered 237 million vaccines in 100 days, and 100 million Americans have now acquired all vaccine doses.

“That’s a hundred million Americans with a sense of relief and peace of mind, knowing that after a long and hard year, they’re protected from the virus,” mentioned Jeff Zients, the White House COVID-19 coordinator. Zients clarified that not all 100 million Americans are thought-about absolutely protected—or 14 days out from their final shot.

He mentioned roughly 40% of Americans are now protected against the worst pandemic the United States has seen because the 1918 influenza pandemic.

“A hundred million Americans who can follow the new CDC [Centers for Disease Control and Prevention] guidance released this week and enjoy going to the park with their family, dining and socializing with their friends outside, and many more outdoor activities without needing to wear a mask,” Zients mentioned.

The federal authorities has distributed greater than 300 million vaccine doses, and Zients mentioned sufficient vaccine has been procured to inoculate each American over the age of 16 throughout the subsequent 31 days.

Moderna CEO suggests 3 vaccine doses wanted

CDC Director Rochelle Walensky, MD, MPH, mentioned the 7-day common of latest COVID-19 instances continued to drop to 52,500 instances per day, about 16% fewer instances than reported within the earlier week.

The United States reported 58,528 new COVID-19 instances yesterday, and 879 deaths, in keeping with the New York Times(*100*). In complete, the nation has confirmed 32,315,363 COVID-19 instances, together with 575,551 deaths.

On common, roughly 2.5 million to three million Americans are getting vaccinated every day, most with mRNA vaccines, which now require two doses. By the top of the 12 months, nevertheless, two doses might turn into three.

Moderna CEO Stephen Hoge mentioned yesterday throughout an occasion hosted on the social media platform Clubhouse that he anticipates a booster dose of the corporate’s mRNA vaccine will want  to be given 9 to 12 months after the second dose of the vaccine.

“Co-administration with an influenza vaccine would be the ideal way to do it,” Hoge mentioned. “One of the things we’re going to look hard at over the summer this year, is how do we create data so that the CDC can provide that recommendation to healthcare systems so that it can be done as a single visit.”

State Department says no journey to India

Late this afternoon, the White House introduced it has directed the State Department to limit vacationers from India starting subsequent Tuesday, primarily based on recommendation from the CDC. Cases in India have been skyrocketing (see associated CIDRAP News story).

Earlier immediately, throughout the press convention, Zients , mentioned the White House was not limiting journey and as an alternative was ensuring those that arrived from India adopted strict quarantine and testing protocols.

However, Jen Psaki, the White House press secretary, mentioned, “The policy [to restrict travel] will be implemented in light of extraordinarily high COVID-19 caseloads and multiple variants circulating in India.”

J&J vaccine outcomes

Also immediately, each JAMA(*100*) and Morbidity and Mortality Weekly Report(*100*) (MMWR) revealed new information regarding hostile outcomes associated to administration of the Johnson & Johnson (J&J, or Janssen) one-dose COVID-19 vaccine.

In JAMA, clinicians describe a case sequence of cerebral venous sinus thrombosis (CVST)  in 12 sufferers following administration of the J&J vaccine. The instances precipitated the Food and Drug Administration (FDA) and the CDC to pause distribution of J&J for 10 days in April.

Of the 12 instances, three have been deadly, three required admission into intensive care models (ICU), two have been hospitalized, and 4 have been discharged to dwelling. All however one affected person offered with extreme headache.

Other sufferers described issue with speech, lethargy, and again and belly ache. Seven of the 12 sufferers had a danger issue for CVST— 6 have been overweight, and 1 used oral contraceptives.

In MMWR, (*100*)authors report a complete of 17 thrombotic events with low platelets following J&J vaccination, three of which have been non-CVST. Overall, 97% of the hostile occasions reported among the many 8 million doses distributed within the United States have been non-serious.

Eighty-eight deaths have been recorded after receipt of the J&J vaccine, however solely three— all CVST — have been related to the drugs.

“The safety profile thus far of the Janssen COVID-19 vaccine is similar to that observed in clinical trials,” the authors concluded.

“A rare but serious adverse event occurring primarily in women, blood clots in large vessels accompanied by a low platelet count, was rapidly detected by the U.S. vaccine safety monitoring system. Monitoring for common and rare adverse events after receipt of all COVID-19 vaccines, including the Janssen COVID-19 vaccine, is continuing.”

In a related MMWR study, consultants describe 64 anxiety-related hostile occasions at 5 mass vaccination websites distributing J&J vaccine. The occasions, which included 17 instances of syncope or fainting, all occurred earlier than experiences of CVST.

None of the anxiety-related occasions have been thought-about critical, however the occasions have been extra widespread than these detected by the Vaccine Adverse Event Reporting System (VAERS) after seasonal influenza vaccination.

The reporting charges of syncope to VAERS after Janssen COVID-19 and influenza vaccines (2019-20) have been 8.2 and 0.05 per 100,000 doses, respectively, the authors mentioned.

Other US developments

  • Disneyland opens immediately for the primary time in 412 days, USA Today(*100*) reported. Capacity on the theme park might be restricted to 25%.
  • Chicago is permitting companies to develop capability limits and planning for summer season festivals in its subsequent section of reopening, WBEZ The metropolis noticed its COVID-19 positivity price drop beneath 5% this week.
  • AstraZeneca executives have struggled to drag collectively the total information vital to use for FDA emergency use authorization (EUA) of its COVID-19 vaccine, the Wall Street Journal(*100*) experiences. The firm had anticipated submitting for an EUA in mid-April, however now says it is probably not till mid-May.

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